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CALCIUM-CHANNEL BLOCKERS AND DISOPYRAMIDE

Medical Diagnosis and Drugs, Medications
Profound hypotension and collapse has occurred in a small number of patients taking verapamil with disopyramide.
The manufacturers warn about combining disopyramide and verapamil (because
of additive negative inotropic effects), but they do point out that in some specific
circumstances the combination may be beneficial. Monitor concurrent use
carefully.
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