CALCIUM-CHANNEL BLOCKERS AND FOOD
The bioavailability of manidipine may be increased by food and the plasma levels of other lipophilic calcium-channel blockers (lercanidipine, nisoldipine) may also be affected.
It has been recommended that manidipine should be given with food. Because of the potential increase in peak plasma concentrations, the manufacturers of lercanidipine and nisoldipine advise giving them before meals (at least 15 minutes before has been recommended).
It has been recommended that manidipine should be given with food. Because of the potential increase in peak plasma concentrations, the manufacturers of lercanidipine and nisoldipine advise giving them before meals (at least 15 minutes before has been recommended).