CALCIUM-CHANNEL BLOCKERS AND MACROLIDES - OTHER CALCIUM-CHANNEL BLOCKERS
Erythromycin markedly increases the bioavailability of felodipine. Isolated reports describe increased felodipine, nifedipine or verapamil effects and toxicity in patients when given erythromycin, clarithromycin or telithromycin. Note that the calcium- channel blockers are all metabolised by CYP3A4, so all have the potential to interact.
Monitor concurrent use. If adverse effects become troublesome (such as hypotension, dizziness, flushing and palpitations) adjust the calcium-channel blocker dose.
Monitor concurrent use. If adverse effects become troublesome (such as hypotension, dizziness, flushing and palpitations) adjust the calcium-channel blocker dose.