CALCIUM-CHANNEL BLOCKERS AND RIFAMPICIN (RIFAMPIN)
The plasma levels of diltiazem, nifedipine, nilvadipine, verapamil and possibly those of barnidipine, isradipine, lercanidipine, manidipine, nicardipine, nimodipine, and nisoldipine are markedly reduced by rifampicin. They may become therapeutically ineffective unless their dosages are raised.
Increase the frequency of blood pressure monitoring and adjust the antihyperten- sive dose, or use an alternative drug, as necessary. Note that the manufacturers of nifedipine and nisoldipine contraindicate their use with rifampicin, and the manufacturer of nimodipine advises against the combination.
Increase the frequency of blood pressure monitoring and adjust the antihyperten- sive dose, or use an alternative drug, as necessary. Note that the manufacturers of nifedipine and nisoldipine contraindicate their use with rifampicin, and the manufacturer of nimodipine advises against the combination.