CALCIUM-CHANNEL BLOCKERS AND SIROLIMUS
The maximum serum levels of sirolimus are raised by diltiazem (43%) and verapamil (over 2-fold). Dosage adjustments may be necessary. Nicardipine is predicted to interact similarly.
The manufacturers recommend monitoring and possible sirolimus dosage adjust- ment if these calcium-channel blockers are used concurrently.
The manufacturers recommend monitoring and possible sirolimus dosage adjust- ment if these calcium-channel blockers are used concurrently.