CAPECITABINE AND PHENYTOIN
Phenytoin toxicity occurred in a patient given capecitabine. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
As this interaction is in line with the way fluorouracil interacts, it would seem prudent to warn the patient to monitor for signs of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness). Take phenytoin levels and adjust the dose as necessary.
As this interaction is in line with the way fluorouracil interacts, it would seem prudent to warn the patient to monitor for signs of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness). Take phenytoin levels and adjust the dose as necessary.