CARBAMAZEPINE AND H2-RECEPTOR ANTAGONISTS
Epileptic patients and subjects taking carbamazepine long-term show a transient increase in serum levels, possibly accompanied by an increase in adverse effects, for the first few days after starting to take cimetidine, but these adverse effects rapidly disappear.
An increase in carbamazepine adverse effects may be seen, and patients should be warned. However, because the serum levels are only transiently increased the adverse effects normally disappear by the end of a week. Ranitidine appears to be a non-interacting alternative to cimetidine, and oxcarbazepine appears to be a non- interacting alternative to carbamazepine.
An increase in carbamazepine adverse effects may be seen, and patients should be warned. However, because the serum levels are only transiently increased the adverse effects normally disappear by the end of a week. Ranitidine appears to be a non-interacting alternative to cimetidine, and oxcarbazepine appears to be a non- interacting alternative to carbamazepine.