CARBAMAZEPINE AND HERBAL MEDICINES OR DIETARY SUPPLEMENTS
St John's wort (Hypericum perforatum) modestly increased the clearance of single-dose carbamazepine, but had no effect on multiple-dose carbamazepine in one study.
Before the publication of these studies the CSM in the UK had advised that patients taking carbamazepine should not take St John's wort. This advice was based on predicted pharmacokinetic interactions. In the light of the above studies, this advice may no longer apply.
Before the publication of these studies the CSM in the UK had advised that patients taking carbamazepine should not take St John's wort. This advice was based on predicted pharmacokinetic interactions. In the light of the above studies, this advice may no longer apply.