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CARBAMAZEPINE AND HRT

Medical Diagnosis and Drugs, Medications
Enzyme-inducing drugs (such as carbamazepine), which increase the metabolism of contraceptive steroids, may reduce the efficacy of HRT.
This effect is most noticeable where HRT is prescribed for menopausal vasomotor symptoms, but might be difficult to detect where the indication is osteoporosis. Any interaction may be less likely with transdermal HRT. However, as yet the clinical significance of any interaction is unclear.
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