CARBAMAZEPINE AND NNRTIS
The concurrent use of carbamazepine and efavirenz leads to a modest reduction in the
plasma levels of both drugs. The use of nevirapine and carbamazepine may also result
in decreased levels of both drugs.
The manufacturers of efavirenz note that an alternative to carbamazepine should
be considered (especially with doses of greater than 400 mg daily). If both drugs
are given it would seem prudent to their monitor plasma levels (where possible),
and efficacy.
plasma levels of both drugs. The use of nevirapine and carbamazepine may also result
in decreased levels of both drugs.
The manufacturers of efavirenz note that an alternative to carbamazepine should
be considered (especially with doses of greater than 400 mg daily). If both drugs
are given it would seem prudent to their monitor plasma levels (where possible),
and efficacy.