CARBAMAZEPINE AND THEOPHYLLINE
Two case reports describe a marked fall in theophylline levels when carbamazepine was given. Another single case report and a pharmacokinetic study describe a fall in serum carbamazepine levels when theophylline was given.
The general importance of these reports is uncertain. Concurrent use need not be avoided, but it would be prudent to check that the serum concentrations of each drug (and their effects) do not become subtherapeutic.
The general importance of these reports is uncertain. Concurrent use need not be avoided, but it would be prudent to check that the serum concentrations of each drug (and their effects) do not become subtherapeutic.