CARBAMAZEPINE AND TIAGABINE
The plasma concentrations of tiagabine may be reduced 1.5- to 3-fold by carbamazepine.
The manufacturers recommend that tiagabine 30 to 45 mg (in divided doses) should be given to patients taking enzyme-inducing antiepileptics such as carbamazepine. A lower maintenance dose of 15 to 30 mg should be given to patients who are not taking enzyme-inducing drugs.
The manufacturers recommend that tiagabine 30 to 45 mg (in divided doses) should be given to patients taking enzyme-inducing antiepileptics such as carbamazepine. A lower maintenance dose of 15 to 30 mg should be given to patients who are not taking enzyme-inducing drugs.