CARBAMAZEPINE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS
The anticoagulant effects of warfarin can be markedly reduced (by around 50% in many reports) by carbamazepine. Acenocoumarol is expected to interact similarly, and cases of this interaction have been seen with phenprocoumon.
Monitor the INR if carbamazepine is added to warfarin therapy. Continue monitoring until the carbamazepine dose is stabilised. Also monitor the INR if the carbamazepine is withdrawn as the effects of warfarin may become excessive within a week.
Monitor the INR if carbamazepine is added to warfarin therapy. Continue monitoring until the carbamazepine dose is stabilised. Also monitor the INR if the carbamazepine is withdrawn as the effects of warfarin may become excessive within a week.