CEPHALOSPORINS AND H2-RECEPTOR ANTAGONISTS
Ranitidine and famotidine reduce the bioavailability of cefpodoxime proxetil. Ranitidine (with sodium bicarbonate) reduces the bioavailability of cefuroxime axetil.
In most cases the interactions between the cephalosporins and H2-receptor antagonists are not clinically significant. The clinical importance of the interaction with cefpodoxime has not been studied, but the manufacturer recommends that it should be given at least 2 hours before H2-receptor antagonists. As it is thought that a change in gastric pH is responsible for this interaction it would seem likely that all H2-receptor antagonists will interact similarly. As long as cefuroxime is taken with food (as is recommended), any interaction is minimal.
In most cases the interactions between the cephalosporins and H2-receptor antagonists are not clinically significant. The clinical importance of the interaction with cefpodoxime has not been studied, but the manufacturer recommends that it should be given at least 2 hours before H2-receptor antagonists. As it is thought that a change in gastric pH is responsible for this interaction it would seem likely that all H2-receptor antagonists will interact similarly. As long as cefuroxime is taken with food (as is recommended), any interaction is minimal.