CEPHALOSPORINS AND PROTON PUMP INHIBITORS
Ranitidine and famotidine reduce the bioavailability of cefpodoxime proxetil. Ranitidine (with sodium bicarbonate) reduces the bioavailability of cefuroxime axetil.
As it is thought that a change in gastric pH is responsible for this interaction it would seem likely that the proton pump inhibitors will interact in the same way as the H2-receptor antagonists. However, as long as cefuroxime is taken with food (as is recommended), any interaction is minimal.
As it is thought that a change in gastric pH is responsible for this interaction it would seem likely that the proton pump inhibitors will interact in the same way as the H2-receptor antagonists. However, as long as cefuroxime is taken with food (as is recommended), any interaction is minimal.