CHLORAMPHENICOL AND CICLOSPORIN (CYCLOSPORINE)
Four patients have shown marked rises in serum ciclosporin levels when treated with chloramphenicol. A small study supports these findings.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if chloramphenicol is started or stopped. Adjust the dose of ciclosporin as necessary. It seems doubtful that there will be enough chloramphenicol absorbed from eye drops to interact with ciclosporin, but this needs confirmation.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if chloramphenicol is started or stopped. Adjust the dose of ciclosporin as necessary. It seems doubtful that there will be enough chloramphenicol absorbed from eye drops to interact with ciclosporin, but this needs confirmation.