CHLORAMPHENICOL AND WARFARIN AND OTHER ORAL ANTICOAGULANTS
Some limited, and poor quality evidence suggests that the anticoagulant effects of acenocoumarol and dicoumarol can be increased by oral chloramphenicol. An isolated report attributes a marked INR rise in a patient taking warfarin to the use of chloramphenicol eye drops.
This interaction is by no means adequately established. There would therefore appear to be little reason for avoiding concurrent use, but be aware that increases in INR are possible. The interaction with chloramphenicol eye drops seems unlikely to be generally relevant.
This interaction is by no means adequately established. There would therefore appear to be little reason for avoiding concurrent use, but be aware that increases in INR are possible. The interaction with chloramphenicol eye drops seems unlikely to be generally relevant.