CHLOROQUINE AND CICLOSPORIN (CYCLOSPORINE)
Three patients had rapid rises in serum ciclosporin levels, with evidence of nephrotoxicity in two of them, when they were given chloroquine. Some loss of renal function has been seen even when low doses of ciclosporin are used with chloroquine for rheumatoid arthritis. Note that hydroxychloroquine may interact similarly.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if chloroquine is started or stopped. Adjust the dose of ciclosporin as necessary.
Ciclosporin levels and/or effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if chloroquine is started or stopped. Adjust the dose of ciclosporin as necessary.