CHLOROQUINE AND PRAZIQUANTEL
Chloroquine reduces the bioavailability of praziquantel, which would be expected to reduce its efficacy in systemic worm infections such as schistosomiasis. Note that hydroxychloroquine may interact similarly.
It has been suggested that an increased dosage of praziquantel should be considered in the presence of chloroquine, particularly in anyone who does not respond to initial treatment with praziquantel. This interaction is not of importance when praziquantel is used for intestinal worm infections (where its action is a local effect on the worms in the gut).
Ciclosporin (Cyclosporine)
It has been suggested that an increased dosage of praziquantel should be considered in the presence of chloroquine, particularly in anyone who does not respond to initial treatment with praziquantel. This interaction is not of importance when praziquantel is used for intestinal worm infections (where its action is a local effect on the worms in the gut).
Ciclosporin (Cyclosporine)