CICLOSPORIN (CYCLOSPORINE) AND CONTRACEPTIVES
Hepatotoxicity has been described in 2 patients taking ciclosporin with oral contraceptives containing ethinylestradiol or desogestrel plus levonorgestrel. The use of norethisterone 10 or 15 mg daily has caused raised ciclosporin levels.
The interactions between ciclosporin and hormonal contraceptives or norethis- terone are unconfirmed and of uncertain clinical significance. There is insufficient evidence to recommend increased monitoring, but be aware of the potential for an interaction in case of an unexpected response to treatment.
The interactions between ciclosporin and hormonal contraceptives or norethis- terone are unconfirmed and of uncertain clinical significance. There is insufficient evidence to recommend increased monitoring, but be aware of the potential for an interaction in case of an unexpected response to treatment.