CICLOSPORIN (CYCLOSPORINE) AND CORTICOSTEROIDS
The concurrent use of ciclosporin and corticosteroids is very common, but some evidence suggests that ciclosporin serum levels are raised by corticosteroids (2-fold by methylprednisolone, and by up to 20% with prednisolone or prednisone). Ciclosporin can moderately increase corticosteroid levels, which may lead to symptoms of overdosage (cushingoid symptoms such as steroid-induced diabetes, osteonecrosis of the hip joints). Convulsions have also been described during concurrent use.
The combination is commonly used, and the case reports and studies document effects well known to be adverse effects of both drugs. The clinical importance of this interaction is probably limited, but if abnormal results occur, remember that this drug combination could perhaps be a cause.
The combination is commonly used, and the case reports and studies document effects well known to be adverse effects of both drugs. The clinical importance of this interaction is probably limited, but if abnormal results occur, remember that this drug combination could perhaps be a cause.