CICLOSPORIN (CYCLOSPORINE) AND FIBRATES
Bezafibrate significantly increased serum creatinine and tended to reduce ciclosporin levels in one study. Deterioration in renal function has also been reported in 5 patients, 4 of whom had no change in ciclosporin levels, and one of whom had increased serum ciclosporin levels. The use of fenofibrate has also been associated with reduced renal function and possibly reduced serum ciclosporin levels. Two studies found no pharmacokinetic interaction between ciclosporin and gemfibrozil while a third found gemfibrozil caused a significant reduction in ciclosporin levels.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if a fibrate is started or stopped. Adjust the dose of ciclosporin as necessary.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if a fibrate is started or stopped. Adjust the dose of ciclosporin as necessary.