CICLOSPORIN (CYCLOSPORINE) AND ORLISTAT
The absorption of ciclosporin is significantly reduced by orlistat (by more than 50% in some cases). In one case, orlistat appeared to have less effect on the microemulsion formulation (Neoral) of ciclosporin than the older formulation (Sandimmun). Never- theless, a non-significant episode of acute graft rejection has been reported with the microemulsion formulation.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it would be prudent to increase monitoring if orlistat is started or stopped. Adjust the dose of ciclosporin as necessary.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it would be prudent to increase monitoring if orlistat is started or stopped. Adjust the dose of ciclosporin as necessary.