CICLOSPORIN (CYCLOSPORINE) AND PHENYTOIN
A study and several case reports describe a reduction in ciclosporin levels (37% reduction in the study) following the addition of phenytoin. Other reports describe the need to make 2- to 4-fold increases in the ciclosporin dose in patients also taking phenytoin.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if phenytoin is stopped, started, or the dose altered.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if phenytoin is stopped, started, or the dose altered.