CICLOSPORIN (CYCLOSPORINE) AND PROTON PUMP INHIBITORS
Studies suggest that omeprazole 20 mg daily does not affect ciclosporin levels, but isolated reports describe doubled serum ciclosporin levels in one patient, and more than halved serum ciclosporin levels in another. Both patients were taking omeprazole 40 mg daily.
This interaction is unlikely to be of general importance, but bear it in mind in case of an unexpected response to treatment, particularly with doses of omeprazole 40 mg daily or above.
This interaction is unlikely to be of general importance, but bear it in mind in case of an unexpected response to treatment, particularly with doses of omeprazole 40 mg daily or above.