CICLOSPORIN (CYCLOSPORINE) AND RIFAMPICIN (RIFAMPIN)
Ciclosporin serum levels are markedly reduced (in some cases within one day) by the concurrent use of rifampicin. Transplant rejection can rapidly develop if the ciclosporin dosage is not increased.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it is essential to increase monitoring if rifampicin is started or stopped. The ciclosporin dose will need to be increased substantially when rifampicin is added (3- to 5-fold increases have been needed in some cases). It has been suggested that other antituberculars should be used in patients taking ciclosporin.
Ciclosporin levels and effects (e.g. on renal function) should be monitored as a matter of routine, but it is essential to increase monitoring if rifampicin is started or stopped. The ciclosporin dose will need to be increased substantially when rifampicin is added (3- to 5-fold increases have been needed in some cases). It has been suggested that other antituberculars should be used in patients taking ciclosporin.