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CICLOSPORIN (CYCLOSPORINE) AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

Medical Diagnosis and Drugs, Medications
Case reports describe decreased warfarin or acenocoumarol effects, which were attributed to an interaction with ciclosporin. Warfarin and acenocoumarol have decreased ciclosporin levels in isolated cases, and a further report describes a rise in serum ciclosporin levels when an unnamed anticoagulant was given.
Information is limited. In patients taking an anticoagulant with ciclosporin, it may be prudent to consider an increase in the frequency of the standard monitoring of both drugs.
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