CILOSTAZOL AND MACROLIDES
Erythromycin increases the maximum plasma level and AUC of cilostazol by 47% and 73%, respectively. Other macrolides may also interact, although it seems unlikely that they all will, see macrolides.
In view of these effects the US manufacturers suggest halving the dose of cilostazol in the presence of CYP3A4 inhibitors such as erythromycin. However, the UK manufacturers contraindicate CYP3A4 inhibitors, and they specifically name erythromycin.
In view of these effects the US manufacturers suggest halving the dose of cilostazol in the presence of CYP3A4 inhibitors such as erythromycin. However, the UK manufacturers contraindicate CYP3A4 inhibitors, and they specifically name erythromycin.