CILOSTAZOL AND PROTON PUMP INHIBITORS
Omeprazole increases the AUC of 3,4-dehydro-cilostazol (a metabolite with 4 to 7 times the activity of cilostazol) by about 70%. Lansoprazole may interact similarly.
The US manufacturers suggest that the dose of cilostazol should be halved when given with omeprazole, while the UK manufacturers suggest that concurrent use should be avoided.
The US manufacturers suggest that the dose of cilostazol should be halved when given with omeprazole, while the UK manufacturers suggest that concurrent use should be avoided.