CINACALCET AND PROTEASE INHIBITORS
Ketoconazole raises cinacalcet levels 2-fold and increased the incidence of cinacalcet
adverse effects, probably by inhibiting the metabolism of cinacalcet by CYP3A4. Other
potent CYP3A4 inhibitors, such as the protease inhibitors, are predicted to interact
similarly.
It may be prudent to monitor parathyroid hormone and serum calcium more frequently in any patient receiving a protease inhibitor.
adverse effects, probably by inhibiting the metabolism of cinacalcet by CYP3A4. Other
potent CYP3A4 inhibitors, such as the protease inhibitors, are predicted to interact
similarly.
It may be prudent to monitor parathyroid hormone and serum calcium more frequently in any patient receiving a protease inhibitor.