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CINACALCET AND RIFAMPICIN (RIFAMPIN)

Medical Diagnosis and Drugs, Medications
Rifampicin is predicted to decrease cinacalcet levels by inducing its metabolism by CYP3A4. This seems a reasonable prediction as potent CYP3A4 inhibitors raise cinacalcet levels.
It may be prudent to monitor parathyroid hormone and serum calcium more frequently if rifampicin is started or stopped.
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