CINACALCET AND SSRIS
Fluvoxamine may decrease the clearance (and therefore increase the levels) of cinacalcet, by inhibiting its metabolism by CYP1A2.
It may be prudent to monitor parathyroid hormone and serum calcium more frequently if fluvoxamine is started or stopped. Note that other SSRIs do not inhibit CYP1A2 and are therefore unlikely to interact by this mechanism.
It may be prudent to monitor parathyroid hormone and serum calcium more frequently if fluvoxamine is started or stopped. Note that other SSRIs do not inhibit CYP1A2 and are therefore unlikely to interact by this mechanism.