CLOPIDOGREL AND SSRIS
The SSRIs may increase the risk of upper gastrointestinal bleeding and the risk appears to be further increased by concurrent clopidogrel.
The manufacturers of the SSRIs warn that patients should be cautioned about the concurrent use of antiplatelet drugs. Consideration should be given to the prescribing of gastroprotective drugs (such as proton pump inhibitors) in those at high risk of gastrointestinal bleeding, such as elderly patients or those with a history of gastrointestinal bleeding.
The manufacturers of the SSRIs warn that patients should be cautioned about the concurrent use of antiplatelet drugs. Consideration should be given to the prescribing of gastroprotective drugs (such as proton pump inhibitors) in those at high risk of gastrointestinal bleeding, such as elderly patients or those with a history of gastrointestinal bleeding.