CLOPIDOGREL AND STATINS
Some evidence suggests that atorvastatin, and possibly other CYP3A4-metabolised
statins (e.g. simvastatin) may interfere with the antiplatelet actions of clopidogrel, but data from some large clinical studies suggests no clinically relevant interaction occurs.
Although an interaction has been demonstrated, the anticipated negative effect on clinical outcomes has not been consistently shown. The beneficial properties of statins may offset any attenuating effects on the antiplatelet action of clopidogrel. Some have suggested that pravastatin and rosuvastatin may be preferred; however others consider there is insufficient data to warrant changing clinical practice, and given the established clinical benefits of the combination, this seems the most appropriate course of action.
statins (e.g. simvastatin) may interfere with the antiplatelet actions of clopidogrel, but data from some large clinical studies suggests no clinically relevant interaction occurs.
Although an interaction has been demonstrated, the anticipated negative effect on clinical outcomes has not been consistently shown. The beneficial properties of statins may offset any attenuating effects on the antiplatelet action of clopidogrel. Some have suggested that pravastatin and rosuvastatin may be preferred; however others consider there is insufficient data to warrant changing clinical practice, and given the established clinical benefits of the combination, this seems the most appropriate course of action.