COLESTYRAMINE AND RELATED DRUGS AND DIURETICS - THIAZIDES
The absorption of hydrochlorothiazide and chlorothiazide can be reduced by more
than one-third if colestipol is given concurrently. Colestyramine also reduces the absorption of hydrochlorothiazide by more than two-thirds.
Separating the dosages of hydrochlorothiazide and colestyramine by 4 hours can reduce, but not totally overcome the effects of this interaction. It may therefore be prudent to ensure a 6-hour separation.
than one-third if colestipol is given concurrently. Colestyramine also reduces the absorption of hydrochlorothiazide by more than two-thirds.
Separating the dosages of hydrochlorothiazide and colestyramine by 4 hours can reduce, but not totally overcome the effects of this interaction. It may therefore be prudent to ensure a 6-hour separation.