CONTRACEPTIVES AND NNRTIS - NEVIRAPINE
Nevirapine modestly reduces the plasma concentrations of ethinylestradiol and norethisterone, which could reduce the efficacy of contraception. The efficacy of emergency hormonal contraceptives and progestogen-only implants or injections may also be reduced by nevirapine.
For general advice on the use of enzyme inducers, such as nevirapine, and contraceptives, see contraceptives. However, note that the manufactur- ers of nevirapine recommend that combined hormonal contraceptives should not be used as the sole method of contraception in women taking nevirapine. They suggest that a barrier method (e.g. condoms) should also be used, and note that this is also advisable to reduce the risk of HIV transmission. They also suggest that if combined hormonal contraceptives are used for reasons other than contracep- tion (e.g. endometriosis), that the therapeutic effect should be monitored and the dose increased if necessary.
For general advice on the use of enzyme inducers, such as nevirapine, and contraceptives, see contraceptives. However, note that the manufactur- ers of nevirapine recommend that combined hormonal contraceptives should not be used as the sole method of contraception in women taking nevirapine. They suggest that a barrier method (e.g. condoms) should also be used, and note that this is also advisable to reduce the risk of HIV transmission. They also suggest that if combined hormonal contraceptives are used for reasons other than contracep- tion (e.g. endometriosis), that the therapeutic effect should be monitored and the dose increased if necessary.