CORTICOSTEROIDS AND MACROLIDES
Clarithromycin and erythromycin can reduce the clearance of methylprednisolone, thereby increasing both its therapeutic and adverse effects. Other macrolides may also interact, although it seems unlikely that they all will, see macrolides.
Appropriate dosage reductions (based on symptoms) may need to be made to avoid the development of corticosteroid adverse effects. Prednisolone seems to be a non-interacting alternative, except possibly in those also taking enzyme inducers (e.g. phenobarbital).
Appropriate dosage reductions (based on symptoms) may need to be made to avoid the development of corticosteroid adverse effects. Prednisolone seems to be a non-interacting alternative, except possibly in those also taking enzyme inducers (e.g. phenobarbital).