CORTICOSTEROIDS AND PROTEASE INHIBITORS
Several cases of Cushing's syndrome have been seen in patients taking inhaled or intranasal fluticasone with ritonavir. Ritonavir may reduce the clearance of prednisone, and ritonavir or nelfinavir may increase levels of the active metabolite of ciclesonide. The manufacturers of betamethasone and budesonide predict a similar interaction with ritonavir or nelfinavir. Dexamethasone may reduce the levels of indinavir and saquinavir.
Monitor concurrent use for signs of corticosteroid overdose such as fluid retention, hypertension and hyperglycaemia. The problem may take months to manifest itself with inhaled corticosteroids. Monitor antiviral efficacy if dexamethasone is given with indinavir or saquinavir.
Monitor concurrent use for signs of corticosteroid overdose such as fluid retention, hypertension and hyperglycaemia. The problem may take months to manifest itself with inhaled corticosteroids. Monitor antiviral efficacy if dexamethasone is given with indinavir or saquinavir.