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CYCLOPHOSPHAMIDE AND DIGOXIN

Medical Diagnosis and Drugs, Medications
Treatment with cyclophosphamide (as part of antineoplastic regimens) appears to damage the lining of the intestine so that digoxin is much less readily absorbed when given in tablet form.
In one of the studies this interaction was overcome by giving the digoxin in liquid or liquid-in-capsule form. Monitor carefully, adjusting dose, drug or preparation as appropriate.
(3)