CYCLOPHOSPHAMIDE AND VACCINES
The immune response of the body is suppressed by cytotoxic antineoplastics. The effectiveness of vaccines may be poor and generalised infection may occur in patients immunised with live vaccines. In one study the antibody response to pneumococcal vaccination was reduced by 60% in patients receiving antineoplastics including cyclophosphamide, and suboptimal responses to influenza and measles vaccines have been reported.
Extreme care should be taken when considering vaccinating immunosuppressed patients, especially with live vaccines, which should generally be avoided. Monitor the immune response to other types of vaccine. Consider whether vaccination can be carried out before or after cyclophosphamide use.
Extreme care should be taken when considering vaccinating immunosuppressed patients, especially with live vaccines, which should generally be avoided. Monitor the immune response to other types of vaccine. Consider whether vaccination can be carried out before or after cyclophosphamide use.