DAPSONE AND RIFAMPICIN (RIFAMPIN)
Rifampicin increases the excretion of dapsone, lowers its serum levels and increases the risk of toxicity (methaemoglobinaemia).
Concurrent use should be well monitored to confirm that treatment is effective. It may be necessary to raise the dosage of dapsone. It has been pointed out that there is a risk of treatment failure for pneumocystis pneumonia as well as for leprosy. Also be alert for any evidence of dapsone toxicity (methaemoglobinaemia).
Concurrent use should be well monitored to confirm that treatment is effective. It may be necessary to raise the dosage of dapsone. It has been pointed out that there is a risk of treatment failure for pneumocystis pneumonia as well as for leprosy. Also be alert for any evidence of dapsone toxicity (methaemoglobinaemia).