DEXTROMETHORPHAN AND SSRIS
A serotonin-like syndrome has developed in several patients taking SSRIs with dextromethorphan, although in many of these cases the use of other drugs with serotonergic actions may have contributed. Hallucinations have been reported in one patient taking fluoxetine with dextromethorphan. Paroxetine and fluoxetine mark- edly inhibit the metabolism of dextromethorphan.
It would seem prudent for patients taking any SSRI to be cautious if using dextromethorphan-containing products because serotonin syndrome, can be serious. The pharmacokinetic interaction between dextromethorphan paroxetine and fluoxetine may increase the risks of this effect.
It would seem prudent for patients taking any SSRI to be cautious if using dextromethorphan-containing products because serotonin syndrome, can be serious. The pharmacokinetic interaction between dextromethorphan paroxetine and fluoxetine may increase the risks of this effect.