DIGOXIN AND PHENYTOIN
Phenytoin moderately reduces digoxin levels, but the clinical significance of this is unknown. There are also isolated case reports of marked bradycardia in patients taking digoxin with phenytoin. Fatalities have been reported when phenytoin was used in cases of suspected digoxin toxicity.
It would seem sensible to monitor the effects of concurrent use and consider monitoring digoxin levels if an interaction is suspected. The use of phenytoin in digoxin toxicity appears to be obsolete.
It would seem sensible to monitor the effects of concurrent use and consider monitoring digoxin levels if an interaction is suspected. The use of phenytoin in digoxin toxicity appears to be obsolete.