DIGOXIN AND PROTON PUMP INHIBITORS
A small rise in serum digoxin levels may occur in patients also given omeprazole, pantoprazole, rabeprazole and possibly lansoprazole. However, these changes are thought to be within the normal variations of digoxin levels and so are not considered clinically significant. However, one patient developed digoxin toxicity 3 months after starting to take omeprazole.
No action needed. The isolated case of toxicity seems unlikely to be generally significant.
No action needed. The isolated case of toxicity seems unlikely to be generally significant.