DIGOXIN AND TRIMETHOPRIM
Serum digoxin levels can be increased by about 22% by trimethoprim, but some individuals may show a much greater rise.
Monitor the effects of digoxin if trimethoprim is given, and consider measuring digoxin levels, particularly in the elderly. Adjust the dose as necessary. Trimethoprim is a constituent of co-trimoxazole but it is not known whether prophylactic doses of co-trimoxazole (160 mg of trimethoprim a day from a 960-mg dose of co-trimoxazole) will interact to a clinically significant degree. An interaction would seem likely with high-dose co-trimoxazole, and care is needed in the elderly with any co-trimoxazole dose .
Monitor the effects of digoxin if trimethoprim is given, and consider measuring digoxin levels, particularly in the elderly. Adjust the dose as necessary. Trimethoprim is a constituent of co-trimoxazole but it is not known whether prophylactic doses of co-trimoxazole (160 mg of trimethoprim a day from a 960-mg dose of co-trimoxazole) will interact to a clinically significant degree. An interaction would seem likely with high-dose co-trimoxazole, and care is needed in the elderly with any co-trimoxazole dose .