DIPYRIDAMOLE AND PROTON PUMP INHIBITORS
The effective disintegration, dissolution and eventual absorption of dipyridamole in tablet or suspension form depends upon having a low pH in the stomach. Drugs that significantly raise the gastric pH are expected to reduce the bioavailability of dipyridamole tablets. This effect has been seen with lansoprazole.
The clinical significance of this interaction is unknown. Bear it in mind if a proton pump inhibitor is given with dipyridamole. Note that modified-release prepar- ations of dipyridamole (that are buffered) do not appear to be affected.
The clinical significance of this interaction is unknown. Bear it in mind if a proton pump inhibitor is given with dipyridamole. Note that modified-release prepar- ations of dipyridamole (that are buffered) do not appear to be affected.