DISOPYRAMIDE AND PHENOBARBITAL
Serum disopyramide levels are reduced by about 35% by phenobarbital. Note that primidone is metabolised to phenobarbital and therefore may interact similarly.
The extent to which this interaction would reduce the antiarrhythmic effects of disopyramide is unknown, but monitor the effects and the serum levels of disopyramide (if possible) if phenobarbital is added or withdrawn. One manufac- turer suggests avoiding the combination.
The extent to which this interaction would reduce the antiarrhythmic effects of disopyramide is unknown, but monitor the effects and the serum levels of disopyramide (if possible) if phenobarbital is added or withdrawn. One manufac- turer suggests avoiding the combination.