DISULFIRAM AND PHENYTOIN
Phenytoin serum levels are markedly and rapidly increased by the concurrent use of disulfiram. Phenytoin toxicity has been seen in 2 patients.
This interaction seems to occur in most patients and develops rapidly. Recovery may take 2 to 3 weeks after the disulfiram is withdrawn. Monitor phenytoin levels carefully during concurrent use. Phenytoin dosage reductions may be needed, but it may be difficult to maintain the balance required.
This interaction seems to occur in most patients and develops rapidly. Recovery may take 2 to 3 weeks after the disulfiram is withdrawn. Monitor phenytoin levels carefully during concurrent use. Phenytoin dosage reductions may be needed, but it may be difficult to maintain the balance required.