DIURETICS AND NSAIDS - POTASSIUM-SPARING DIURETICS

The manufacturer advises caution on the concurrent use of NSAIDs and eplerenone because NSAIDs can cause renal impairment, especially in dehydrated or elderly patients. Several cases of acute renal failure have been seen when triamterene was given with NSAIDs.
Patients should be well hydrated and have their renal function checked before starting this combination.