DULOXETINE AND TRICYCLICS
Duloxetine markedly increases the AUC of desipramine. Other tricyclics metabolised by CYP2D6, such as nortriptyline, amitriptyline and imipramine, may interact similarly. The use of duloxetine with other serotonergic drugs, such as the tricyclics, may increase the risk of serotonin syndrome.
The manufacturer advises caution on concurrent use. Monitor for duloxetine adverse effects, and for signs of serotonin syndrome.
The manufacturer advises caution on concurrent use. Monitor for duloxetine adverse effects, and for signs of serotonin syndrome.